distribution of class i integron among isolates of acinetobacter baumannii recoverd from burn patients
نویسندگان
چکیده
b ackground : acinetobacter baumannii , is an important opportunistic pathogens responsible for nosocomial infections. the aim of this experiment was to determine prevalence of class i integron in a. baumannii strains isolated from burn patients in mottahari hospital and the drug susceptibility pattern. methods : there were 69 acinetobacter isolates, 68 (98.5%) were identified as a . baumannii . antimicrobial susceptibility of these isolates were determined by a disk diffusion method. pcr assay for detection of bla oxa-51 like gene (for identity confirmation) and inti was performed. r esults : the most effective antibiotic for treating a. baumannii was colistin, followed by tetracyclin and tobramycin. the presence of integron class i was detected in 14.49% of isolates. esbl and carbapenemase production were observed in 10% and 24.6% of isolates, respectively. conclusion : due to the high resistance of strains lacking integron i, the findings are although class i integrons are disseminated among clinical isolates of a. baumannii , at present research, they they do not play important role in dissemination of antibiotic resistance genes in mottahari hospital in tehran, iran.
منابع مشابه
Novel rearrangement of a class 2 integron in two non-epidemiologically related isolates of Acinetobacter baumannii.
Tn7::In2-8 contains sat2-aadB-catB2(deltaattC)-dfrA1-sat2-aadA1-orfX in the variable region of a class 2 integron embedded in the Tn7-like transposon. This novel transposon was inserted in its preferred site downstream of the glms gene in Acinetobacter baumannii. Acquisition of the pseudocassette catB2 could have arisen by a secondary-site integrase-mediated intermolecular recombination event.
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عنوان ژورنال:
journal of medical bacteriologyجلد ۲، شماره ۱-۲، صفحات ۱-۱۱
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